摘要 多肽聚合物是能够自组装成超分子的新型生物材料，可用于穿透生物膜进入细胞的药物输送，尤其是在脑部疾病、再生药物和癌症治疗领域中有创新性的应用。
多肽聚合物一般由8-30个氨基酸通过肽键连接组成，多肽中极性氨基酸组成了多肽聚合物的亲水区，多肽的非极性区通常由非极性的或芳族氨基酸和烷基、酰基或芳基油脂构成。
多肽聚合物中亲水部分和疏水部分平衡的变化会导致超分子结构的改变，超分子结构的稳定性通常是通过疏水作用、静电作用、 beta;折叠以及pi;-pi;之间相互作用来维持。
在水性环境中，多肽聚合物的大小、形状和界面的弯曲都是上述各作用力复杂作用的结果。
目前许多的多肽类药物都处于临床前的研究阶段。
本文讨论了多肽聚合物在药物传递过程中自组装成超分子的基础构架。
关键词 多肽；自组装；药物传递；驱动力Research and Application of Peptide self-assembly for Drug DeliveryAbstract A polypeptide polymer,a new engineered biomaterials that is able to self assemble into supramolecular systems, can be used to penetrate the biological membrane and deliver drug into the cell, especially in the field of brain diseases, regenerative medicine and cancer therapy.Polypeptide polymer is aminoacid block co-polymers, with a peptide backbone composed usually of 8-30 amino acids, a hydrophilic block formed by polar amino acids and an apolar block which usually entails either apolar or aromatic amino acids and alkyl, acyl or aryl lipidic tails and in some cases a spacer or a conjugated targeting moiety. Alteration in the balance between the hydrophilic and hydrophobic blocks result in a range of supramolecular structures that are usually stabilised by hydrophobic, electrostatic, beta;-sheet hydrogen bonds and pi;-pi; stacking interactions. In an aqueous environment, the final size, shape and interfacial curvature of the polypeptide polymer is a result from the complex interplay of all interactions. Lanreotide is the first PA to be licensed for the treatment of acromegaly and neuroendocrine tumours as a hydrogel administered subcutaneously, while a number of other polypeptide polymer is undergoing preclinical development. This review discusses PAs architecture fundamentals that govern their self-assembly into supramolecular systems for applications in drug delivery.Keywords Polypeptide polymer; Self-assembly;Applications; Drug delivery;Driving forces1.前言生物药物可以通过与细胞外的靶点结合而具有高效、高选择性的特点，并且与小分子的APIs相比其风险更小[1]。
与重组蛋白质和抗体相比，多肽的分子量小、免疫原性低，能够更深地渗透进入组织[1]。
在追求降低医疗保健药品成本、增加药物种类以及提高药物安全性、有效性的压力下，近年来在医药市场上激起了研究多肽、蛋白质、抗体等生物技术制剂的浪潮。
工业生产的治疗用肽聚合物的制造成本低，单位质量的活性更高，具有更高的稳定性以及降解产物的系统毒性更小的特点。
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